The 3 R's are guiding principles for the humane use of animals in science and were first expounded as such by Russell and Burch in 1959. They may be presented as follows:

replacement: the use of non-animal methods such as cell cultures, human volunteers and computer modelling instead of animals to achieve a scientific aim.

reduction: the use of methods that enable researchers to obtain comparable amounts of information from fewer animals, or more.

refinement: the use of methods that minimise potential pain, suffering or distress, and that enhance animal welfare for those animals that cannot be replaced.

Hardware and software developed by emka TECHNOLOGIES contribute to the replacement, reduction and refinement of animal use in preclinical research. While replacement is the ultimate goal, it is not always achievable or feasible, particularly in the field of toxicology - in this case, efforts are concentrated on reduction and refinement.

>> click here to read more.

rodentPACK - wireless, low cost, head-mounted eeg for rats

The rodentPACK transmits data via radiotelemetry, offering a well-tolerated, humane alternative to tethered eeg. It is the only head-mounted radiotelemetry device that allows for pair or group housing. Direct inputs from the device to cortical and deep brain regions provide a high signal to noise ratio, facilitating the detection of eeg events. Because the body of the rodentPACK is externally mounted, the same transmitter can easily be connected to any implanted animal, and the battery can be replaced. Each rodentPACK provides two eeg inputs, emg, ecg, and 3-axis acceleration, with analog outputs. learn more

emkaBATH4 - a self-contained tissue bath with an intelligent design.

The emkaBATH4 is a modular tissue bath, which allows the investigator to choose from a range of bath sizes and tissue hook designs. It uses an electric heating system combined with pre-heating of the buffer solution for more stable and reliable temperature control. All tissue bath operations are accessible from within our acquisition software, so bath filling and emptying and tissue tension operations are set in the acquisition protocol, without the need for a separate application. learn more

ecgTUNNEL - acquire ecg noninvasively from conscious rats and mice

The ecgTUNNEL allows for the acquisition of 1 to 6-lead surface ecg from conscious, restrained rodents of various sizes, including neonates. The system is quick and easy to set up. Up to 16 tunnels can be used simultaneously, making the device ideal for high-throughput screening of animals for cardiac arrhythmias and conduction abnormalities. learn more

Come read our latest testimonial: ecgAUTO was very important for the completion of several of our studies including the one on the electrical remodelling of mice overexpressing the human type 1 angiotensin II receptor (AT1R) specifically in cardiomyocytes. >> read more...

Céline Fiset, Ph.D. - Montreal Heart Institute - Montreal, QC, Canada and Pierre Paradis, Ph.D. - Jewish General Hospital - Montreal, QC, Canada

emka TECHNOLOGIES is able to provide all the equipment you need to study of cardiac conductivity:

• electrophysiology catheters
• electrophysiology stimulators
• amplifiers
• acquisition and analysis software

Electrophysiology catheters include the Millar EPR-800 with 8 electrodes along its length and suitable for mice as small as 2.5g... click here to learn more about our solutions forthe study of cardiac conductivity .

glp compliance facilitates the conduct of studies, promotes their full and accurate reporting, and guarantees data integrity.

All emka TECHNOLOGIES software is 100% compatible with glp requirements for strict toxicology, safety pharmacology, and general pharmacology applications. They also provide you with an easy and reliable solution for a 21 cfr part 11-compliant environment.

software features include:

• data integrity and accountability
• electronic signature
• usersMANAGEMENT software to define users' access rights levels,
• login & passwords, validity etc.
• auditSERVER to trace all actions done on the set-up in an encrypted file
• audit-viewer to quickly review audit-trail lines
• Microsoft Excel® macro to export, filter and check the audit-trail files
• direct link for secure data transfer to your in-house database or LIMS

http://pulmonary.emka.fr/

On this site, you can find out about our comprehensive range of solutions for studying pulmonary function: plethysmography, pulmonary mechanics, exposure studies, aerosol, noninvasive telemetry lung volume measurement…

In addition, you can find out which system is right for your needs; read FAQs; download our literature; find out who our customers are and how they are using our systems (downloadable articles).

To receive an itemized quote in your mailbox, answer a few simple questions on the "Ask for a Quote" page.

Please explore the site and let us know what you think!

The PV loops analyzer of iox2 software performs analysis on loops during steady-state and changing conditions (e.g. vena cava occlusion). Parameters from steady-state loops are calculated in real-time on a beat-by-beat basis. The analyzer processes occlusion loops (selected by user) to generate several parameters and graphs: end-systolic pressure-volume relationship (ESPVR); end-diastolic pressure-volume relationship (EDPVR); preload recruitable stroke work (PRSW); dPdtmax vs end-diastolic volume relationship; maximal elastance...

The pressure and volume signals are obtained using a conductance catheter and signal conditioner. Millar hardware is available from emka TECHNOLOGIES.

For more information about PV loop analysis in iox software and Millar hardware:
http://www.emka.fr/pv-systems-30-h-17.html

Cardiac contractility can also be assessed by analyzing pressure-distance loops. The distance input is typically myocardial segment length or wall thickness measured by sonomicrometry transducers. A dedicated iox analyzer is available for this purpose.

emka TECHNOLOGIES' iox can be used to record the bp signal. After acquisition, ecgAUTO analyzes the recorded data for sequences of beats in which the beat-to-beat interval duration and blood pressure change in the same direction. The slope of each sequence on an x-y plot is an index of baroreflex sensitivity.

Visit our website to find out more about baroreflex sensitivity and ecgAUTO. For further information or to place an order, contact one of our salespeople.

solutions for primates

Primates are intelligent, social animals with a complex range of both physical and emotional needs. Insuring the comfort and welfare of primates while maximizing experimental data integrity provides a unique challenge.

emka TECHNOLOGIES provides a complete array of products uniquely suited for the acquisition and analysis of physiological data from nonhuman primates.

• noninvasive telemetry
• implantable telemetry
• innovative software solutions
• observational data

click here to learn more

Please contact us to see how we can help you meet your primate research goals.

Looking for a smarter way to integrate your pulmonary physiology research needs?

emka TECHNOLOGIES is pleased to offer complete solutions for pulmonary physiology labs.  Our software & hardware is designed for efficiency and flexibility for both academic & industry research environments.  Our pulmonary systems provide comprehensive, real-time, breath-by-breath analysis of physiologic signals from a variety of plethysmography designs including:

whole body, unrestrained
head-out
double chamber
resistance/compliance
large animal helmet

Let our software provide you with powerful feedback via real-time trends, data tables, and user defined rejection criteria.  Use the same software to integrate & automate external device triggers for control over nebulizers, infusion pumps, & other hardware units.

For the ultimate in system integration, let emka TECHNOLOGIES design a system that incorporates your other physiologic end points with your pulmonary data.  Our modular approach to signal analysis makes it possible to simultaneously acquire and analyze data from:

cardiovascular
electrophysiology
neurophysiology
integrated video

innovative data analysis options include:

HRV analysis
sleep scoring
cough detection
apnea detection

the cigarette smoking robot (Scireq) is now available!

The robot lights cigarettes then ejects them when they are finished. Up to 24 cigarettes can be 'smoked' in a user-defined order - any combination of sequential or parallel smoking is possible.

The cigarette smoking robot is part of the inExpose system configured for cigarette smoke exposure experiments. The computer-controlled pumps of the inExpose permit virtually any puffing profile to be produced. Standardized profiles are predefined in the software.

contact us to find out more about the capabilities of inExpose or for sales enquiries

emkaBATH4 IS the outcome of emka TECHNOLOGIES' long experience in the field of isolated tissue study.

Its key characteristics are as follows:

To find out more about the emkaBATH4 or to place your order, visit our website or contact us.

emka TECHNOLOGIES is the first company to offer the preclinical community the possibility of obtaining completely non-invasive blood pressure (nibp) measurements from freely moving animals.

The O.P.T. (oscillometric pressure telemetry) module is available as an option with the emkaPACK telemetry system. Our method of measuring blood pressure offers several valuable advantages, including:
- very low recurring costs
- rejection of noisy waveforms
- beat-by-beat review and editing

The system is undergoing testing by a CRO. Preliminary results were presented recently at the 2009 meeting of the Society of Toxicology in Baltimore; they show that, after 1000 hours of recording from 40 dogs, reliable data were produced from 60% to 90% of inflation/deflation cycles.

On our telemetry website, you can find more information about the non-invasive blood pressure O.P.T. module or contact us with your queries.

emka TECHNOLOGIES is pleased to announce that we have joined the Facebook social network.

After you have signed in, do a search for emka TECHNOLOGIES and you will see our page in the results. Take a look around and then become a Fan to receive alerts about updates to the page (new products, events, photos…)

http://www.facebook.com/pages/emka-TECHNOLOGIES/130135760225

The ecgTUNNEL range from emka TECHNOLOGIES can be used to measure 6-lead ecg in a non-invasive manner from conscious mice or rats.

Mouse models have already been launched and are in use by customers. To satisfy additional requests, we developed the rat models.

For either model, we offer different sized tunnels to firmly and gently restrain neonate to adult rodents. Furthermore, we can provide the equipment to use the ecgTUNNEL as part of a wired or a wireless setup. On the software side, iox and ecgAUTO perform acquisition and ecg analysis, respectively.

Find out more about the ecgTUNNEL or contact us.

emka TECHNOLOGIES releases version 2.5 of studyDESIGNER, its software for planning and managing safety pharmacology and toxicology studies.

This version further improves performance, ease of use, and flexibility.

Key features are as follows:

studyDESIGNER version 2.5 is compatible with iox version 2.

Click here for more information about studyDESIGNER or contact us.

emka TECHNOLOGIES is proud to announce the official launch of its telemetry minisite at:

The minisite contains a wealth of information about telemetry systems from emka TECHNOLOGIES: the different types of setups, with detailed description of different components; how to find the right system for your needs; FAQs; literature to download; list of customers and how they are using telemetry; possible combinations of signals etc.

The telemetry minisite is the first of a serie to come. Each will be a full-featured website exclusively focused on a single application.

Please explore the site and let us know what you think!

SOT presentation on advances in telemetric nibp recording

To find out why non-invasive blood pressure recording has become an alternative to implants, join us at our presentation at the meeting of the Society of Toxicology (Baltimore, Maryland; 16-17 March 2009):

non-invasive blood pressure measurements on ambulatory large animals

12:15 - 1:15 on Tuesday, 17 March
Room assignment: 338
Lunch will be provided.

We will also be presenting for the first time results of tests carried out by a CRO (CIT) with our nibp system and an implanted transmitter.

And don't forget to visit booth #1655 in the exhibit hall to discover and learn more about our comprehensive range of software, hardware and services for the life sciences community.

We look forward to seeing you!

telemetry in primates

The non-invasive emkaPACK telemetry system from emka TECHNOLOGIES is suitable for use in primates such as the cynomolgus monkey.

It can be used to record 7-lead ecg for up to 3 consecutive days, but also skin temperature, activity and respiration. Subjects may be individually or group housed (custom-designed clothing has been tested in real-world conditions).

For more information about the emkaPACK telemetry system, click here

Contact us to find out more about telemetry in primates.

inExpose - inhalation exposure in rodents

emka TECHNOLOGIES is proud to offer the Scireq inExpose system for studying the effect of exposure to different substances.

The primary use is in inhalation experiments in rats and mice, using a whole-body chamber or a nose-only mask. However inExpose is also used in experiments with large animals (face mask) and tissue cultures.

It can be used for exposure to aerosolized liquids, suspensions and powders, toxins, vapors, gases… Notably, several accessories have been developed to meet the varying needs of researchers studying the effects of cigarette smoke.

The data acquisition software can be used to precisely adjust different exposure parameters, including exposure and nebulization profiles.

emka TECHNOLOGIES provides simple solutions to allow you to monitor eating and drinking behaviour in rodents.

Animal cages are adapted to receive food and drink holders. Each holder is fitted with a force transducer that is connected to iox acquisition software - up to 32 cages can be monitored simultaneously.

A specific iox analyzer quantifies intake, providing answers to questions like "How many times does the subject eat/drink during the day and during the night?" or "How much food/ drink is consumed each time?"

The analyzer also provides parameters related to visits without intake (for example subject poking around), so that other behavioural patterns may be detected.

Click here for more information or contact us.

"Automatic beat selection" is a new feature in iox, data acquisition and real-time analysis software from emka TECHNOLOGIES.

iox selects beats using a protocol created by the user. A protocol consists of a set of instructions, each of which selects a single beat in relation to user-defined experimental marks (periods and comments). For example, "select a beat at 2 minutes after the start of the period named Low Drug Concentration".

Our software engineers primarily developed automatic beat selection for researchers performing electrophysiological studies: the ability to select action potentials using a protocol is a valuable time-saving device.

Selected beats are transferred to the Beat report panel, where changes are visible at a glance. In the screenshot below, we can see that the drug product has a clear effect on the ventricular action potential.

Automatic beat selection is one of the new features of iox version 2.5, to be launched soon. Click here to find out more about iox or contact us for information about upgrading. 

emka TECHNOLOGIES is proud to offer the Scireq flexiVENT system for measuring respiratory mechanics and lung function in animals from under 10 g to over 45 kg.

flexiVENT combines a computer-controlled high-precision ventilator with glp-compliant software for acquisition and analysis. Respiratory mechanics parameters are calculated from data collected during a brief interruption to the ventilation (the perturbation).

flexiVENT is suitable for use in different applications: thoracic imaging, total liquid ventilation and isolated airway experiments.

Click here for more information or contact us.

emka TECHNOLOGIES will be participating as an exhibitor and presenter at the 48th annual meeting of the Society of Toxicology (SOT), on March 16-17th, 2009 in Baltimore, Maryland.

Visit us at booth #1655 in the exhibit hall to discover and learn more about our comprehensive range of software, hardware and services for the life sciences community.

We will be presenting results of tests carried out jointly with CIT (CRO based in Evreux, France) comparing blood pressure measurements obtained with our tail cuff (nibp option with our emkaACK telemetry transmitter) and with an implanted transmitter.

We look forward to seeing you! For more information, click here.

emka TECHNOLOGIES can provide full setups to study thrombosis-related phenomena in rats or mice, whether to increase understanding of physiological thrombosis formation or to assess the properties of drugs.

In anesthetized mice, for example, one can quantify thrombosis formation by measuring carotid artery flow rate downstream of the thrombus. This particular setup, as most others, uses flow probes and control units by Transonic Systems Inc. which feed data into iox2 acquisition software. iox2 can also perform real-time analysis with the use of specific add-on blood flow analyser.

For more information, click here.

emka TECHNOLOGIES is committed to the continued production of open data acquisition and analysis systems. An open system allows software and hardware from multiple manufacturers to be used together, in any combination that suits the investigator's needs. Open systems can lower cost sand offer enhanced features not available in closed, proprietary systems.

Read more and discover the advantages of open systems, click here.

The microvessel myograph from emka TECHNOLOGIES is designed for the study of vessels with a diameter of 100µm to 2mm and a maximum length of 3.5mm. The transducer measures contractile forces of up to 10g.

Two models are available, with 1 bath (20ml) or 2 baths (2 x 3ml, 2 x 5ml, or 2 x 10ml).

emka TECHNOLOGIES can supply all that is necessary to start running experiments, including an amplification system, heater/pump for heating fluid, acquisition software and carbogen bottles. The carbogen provides the necessary oxygenation and also "pushes" the physiological solution into the baths (i.e. the system does not rely on a pump or the force of gravity for this purpose). A vacuum source is also required - if your laboratory does not have one, our technicians can install a vacuum pump with automatic switch.

For more information about the the microvessel myograph, click here.

emka TECHNOLOGIES also supplies single (click here) and 4-bath systems (click here) for the study of larger vessels.

emka TECHNOLOGIES is delighted to introduce emkaPACK non-invasive telemetry for research studies on rabbits.

The telemetry system is currently used in dogs, primates and swine by pharmaceutical companies and CROs worldwide.

Testing showed that data acquired from rabbits were of comparable high quality: 4 electrodes and 2 belts were connected to the emkaPACK for the acquisition of 6-lead ecg, lung volume and activity parameters. Signals could be processed without difficulty in iox and ecgAUTO.

For more information about the emkaPACK telemetry system, click here.

Contact us to find out more about telemetry in rabbits.

emka TECHNOLOGIES provides complete hardware and software solutions for plethysmography studies in mice, rats or guinea pigs

Our range of whole-body plethysmographs - in which the subject is conscious and freely moving - continues to expand.

The latest model has a removable tower, and therefore offers all the advantages of previous models with added flexibility. Changing between tower-on or tower-off configurations takes less than 30 seconds.

In tower-on mode, fluid lines and/or wires can be used to simultaneously measure non-pulmonary parameters (blood pressure, blood flow, ecg, eeg, …), and perform blood sampling and/or drug injections.

To find out more about the whole-body plethysmographs with removable tower, click here.

Click here to see how this model has already been adapted for a CNS research team - if you have a specific need, however simple or complicated, contact us now !

 Setups for measuring non-invasive blood pressure (nibp) are based on the principle of blood flow occlusion using a cuff placed around the subject's tail.emka TECHNOLOGIES offers CODA systems (Kent Scientific Corp.) for measuring the following nibp parameters from rats or mice:

 systolic blood pressure
 diastolic blood pressure (please note that this parameter is not measured but calculated in some other nibp systems)
 mean blood pressure
 heart rate
 blood flow
 blood volume

The sensors in CODA systems use volume pressure recording technology, a clinically validated technology providing virtually 100% correlation with direct blood pressure measurements.

The systems are supplied as complete acquisition systems, including hardware controllers, restrainers, cuffs and software. They can be used for acquisition from 2, 4, 6 or 8 subjects simultaneously (CODA 2 to CODA 8).

For more information, see our website or contact us here.

This compatibility opens up several data acquisition possibilities.

For pulmonary studies, resistance and compliance measurements can be made in conscious restrained rat or mice, with the pressure signal coming from DSI^TM implants and the flow signal from emka TECHNOLOGIES' head-out plethysmograph.

The study of cardiorespiratory function in rodents is another option. In this case, pulmonary, blood pressure and ecg data are recorded simultaneously by combining DSI^TM implants with a whole-body plethysmograph setup from emka TECHNOLOGIES. Such a setup is discussed below for rats.

For more information, see our website or contact us here.   

These forces are constantly adapting to the body's requirements and ever changing internal and external conditions. The hemodynamic state is defined by pressure and flow.

The miniaturization of sensors has made it feasible to study hemodynamics in anesthetized rats and mice. All hardware and software for running such experiments are available from emka TECHNOLOGIES.

For more information, see our website or contact us here.  

The minipig offers several advantages as a second and even first non-rodent species in safety studies. Use of minipigs is now well established for invasive and non-invasive cardiovascular safety pharmacology studies. In this respect, emka TECHNOLOGIES can supply and install necessary hardware and software, and provide other valuable services such as training, ongoing support and maintenance, and validation. emkaPACK non-invasive telemetry system for minipigs.

The system developed by emka TECHNOLOGIES provides a method to monitor subjects utilizing non-invasive telemetry.

the best solution for studies with non-invasive telemetry

• to 7-lead ecg
• respiration
• activity
• group housing

• synchronized video all-in-one file:
• click the waveforms and see the corresponding images

ecgAUTO: the best integrated digital solution for ecg studies
Our industry leading ecg analysis software ecgAUTO offers several features to allow you to fully exploit your data

For more information, see our website or contact us here. 

A cylinder-shaped tube restrains the subject firmly and gently, without causing trauma. Four electrode pads on the floor of the ecgTUNNEL allow you to obtain 1- to 6-lead ecg data.

The key advantages of this method - no surgery, no anesthetic, quick and easy setup, short adaptation time - can help you increase productivity particularly when screening subjects to be further investigated.

ecgTUNNEL can be used in combination with ecg amplifiers or as part of a wireless setup (with emkaPACK non-invasive telemetry system).

The following article gives a valuable overview of the ecgTUNNEL from the researcher's point of view:
H. Mongue-Din & A. Salmon & M. Y. Fiszman & Y. Fromes (2007) Non-invasive restrained ecg recording in conscious small rodents: a new tool for cardiac electrical activity investigation. Eur J Physiol 454:165-171

For more information about ecgTUNNEL, see our website or contact us here.

emka TECHNOLOGIES offers several purpose-built modules within both our iox2 data acquisition software for real-time analysis, and ecgAUTO software for advanced in-depth post-processing) for analyzing cardiac action potentials :

• monophasic action potential (MAP) analyzer for compound action potentials recorded from the endocardium or epicardium of the intact heart
• ventricular action potential (VAP) analyzer to study action potentials from cells in the ventricle, including Purkinje fibre cells
• nodal action potential (NAP) analyzer to study action potentials from pacemaker cells from the sinoatrial or atrioventricular nodes

Measured parameters: resting membrane potential, maximum diastolic potential, baseline voltage, maximum rate of depolarization, amplitude of action potential, duration of action potential, absolute and effective refractory period...

Other products from emka TECHNOLOGIES can also assist you in your cardiac safety studies:
• complete integrated setup for isolated heart studies (Langendorff or working heart)
• complete integrated solution for whole-animal safety studies (with emkaPACK non-invasive telemetry ), including ecgAUTO, our industry-leading ecg analysis software

Our knowledge base article "Why are AP measurements important and what is VAP ?" describes a key aspect of cardiac safety testing, QT assessment, and the importance of the hERG receptor.

For more information about incorporating emka TECHNOLOGIES software and hardware into your cardiac safety tests, contact us .

In recent years, a combination of factors including the increase of serious cardiac adverse events and the withdrawal of pharmaceutical products from the market, has forced cardiac safety testing, and especially earlier screening of hERG, Action Potentials, and particularly QT assessment, to the top of the agenda of the preclinical research community.

Recording and analyzing action potentials is one way of assessing QT.

To Perform your early cardiac safety tests, emka TECHNOLOGIES has complete integrated setups that will take you from isolated organ to whole animal. For isolated organ our automated high throughput isolated heart system will aid you in performing some of these earliest safety studies (both Langendorff and working heart modes available) Whole-animal later stage safety studies can be performed with our emkaPACK non-invasive telemetry system (7 Lead ECG, Dual Band Respiration, BP, and Activity).

emka TECHNOLOGIES has developed an ecg amplifier for performing ecg toxicology studies in a glp-compliant environment.

The mainframe houses a card for 6 standard ecg leads and, optionally, a card for 6 precordial ecg leads, allowing for the acquisition of 6- or 12- lead ecg. 

The mainframe connects directly to the acquisition card on the PC, eliminating the need for an interface box. Given that 12 channels are reserved for ecg acquisition; channels 13-16 can be used for the acquisition of other signals as desired (via bnc connectors on the mainframe). 

To satisfy glp requirements, there are no connectors or user accessible settings on the cards (only a switch to select calibration or measurement modes).

For more information about ecg amplifiers for toxicology studies, see our website or contact us here.

emka TECHNOLOGIES provides complete hardware and software solutions for plethysmography studies with anesthetized subjects, for real-time direct measurement of airway mechanics - resistance and compliance - as well as standard respiratory parameters.

Subjects may be ventilated or breathing spontaneously. The standard hardware includes a whole-body plethysmograph fitted with a pneumotachograph, two differential pressure transducers and bridge amplifiers.

At the software end, real-time analysis is done in emka TECHNOLOGIES data acquisition software, iox2, with the rc (respiratory compliance) analyzer.

Add-on options allow for delivery of aerosol and/or anesthetic gas to the plethysmograph. The nebulization system for aerosol delivery is a complete system (aerosol generator, nebulization controller device, bias-flow pump etc), which integrates fully into the plethysmography setup.

Numerous options also exist to monitor the vital status of ventilated subjects: blood pressure measurement, oximetry and ecg.

To find out more about measuring lung resistance and compliance, see our website or contact us here.

I want to choose the right software for my research but it's not the easiest of tasks!

In recent years, preclinical research has evolved considerably to exploit the benefits of wireless communications. The most obvious manifestation has been the advent of telemetry systems providing higher quality data generated by less stressed subjects, especially in the case of non-invasive recordings.

Software has also had to adapt, to efficiently and reliably handle increasing amounts of data associated with continuous recordings. The upward trend is set to continue as installations become larger and video becomes commonplace.

In this context, choosing acquisition and analysis software really able to enhance your research productivity is not an easy task, especially when one of your key objectives should also be to have an open system, avoiding being tied to a single vendor.

Click here to read the rest of the article. Discover our non-invasive telemetry systems.

Isometric transducers measure force generated during isometric contraction (defined as contraction without change in length).

The two models available from emka TECHNOLOGIES, it1 and it50, are designed for use with the integrated 4-bath setup, which is used to study isolated tissues, such as aorta, trachea and papillary muscles, during drug exposure or electrical stimulation.

it1 and it50 should meet the needs of all researchers performing such experiments. it1 was designed for researchers seeking high precision and high sensitivity; for the development of the it50, some precision was sacrificed to give a more robust product. The key technical specs are given below.

it1:  measurement range 0 – 25 g (0 to 0.25 N); sensitivity  > 10 μV/g/V (5 mV full scale output); combined error (linearity, hysteresis, repeatability, temperature) < 0.2 % of measurement range.

it50:  measurement range 0 – 50 g (0 to 0.5 N); sensitivity > 0.8 mV/g/V (200 mV full scale output; combined error (linearity, hysteresis, repeatability, temperature) < 0.2 % of measurement range.

For more information about isometric transducers, visit www.emka.fr or send us your request here.

The nebulizationCONTROLLER from emka TECHNOLOGIES may be used with an aerosol delivery system fitted to a plethysmography setup.

Each nebulizationCONTROLLER controls up to four nebulization heads (Aeroneb Aerogen nebulizers), allowing for the delivery of a fine-droplet aerosol to four plethysmographs. Several functions become available to the user when nebulizationCONTROLLERS are used in the aerosol delivery system:

• you can adjust nebulization rate
• you can control nebulization remotely from iox2 software
• you can incorporate nebulization tasks into iox2 protocols, and let iox2 do the work for you!

Furthermore, when a series of nebulizationCONTROLLERs are chained together, iox2 can control nebulization heads independently, and simultaneous aerosol delivery becomes possible.

For more information about our nebulizationCONTROLLER and plethysmography setups, or for an on-site demonstration,  visit http://www.emka.fr/index.php?page=30&hardware=29&produit=76

SOT 2008 - March 16-20, 2008 - Washington State Convention & Trade Center - Seattle, Washington - booth#620

emka TECHNOLOGIES has developed smart solutions for many applications: non-invasive telemetry, ecg analysis, synchronized video, action potential, pulmonary applications, study management

We are the first and leading provider of shape recognition ecg analysis - come visit us! booth#620

What you should know before you design, build and equip your facility to conduct experiments with large populations using non-invasive telemetry.

When planning studies involving a high number of telemetered subjects, and hence a large experimental area, an obvious design consideration is hardware infrastructure. For example, effective management of several telemetry devices requires a single remote center from which the entire system can be monitored, controlled and operated. The architecture must also allow for distant computers to perform tasks such as: recording start and stop; real-time data control and visualization; hardware monitoring; data post processing; review and editing; database management; backup and archiving services; secured links to in-house LIMS. And all of this bearing in mind the large volume of data involved, especially now that video is frequently added to physiological data.

These requirements, compounded by obligations to comply with GLP and internal IT rules, make the choice of an ideal system all the more difficult. Large telemetry projects require in-depth case-by-case engineering design based on novel and powerful data and network management technologies.

Read full article here. Discover our non-invasive telemetry systems.

emka TECHNOLOGIES provides complete hardware and software solutions for PV loop studies. Conductance catheters and signal conditioners are available for a range of species, from mice and rats (Millar) to large animals (Leycom).

Real-time complete analysis can be performed using a specific analyzer with emka TECHNOLOGIES' iox2 data acquisition software. Researchers performing PV loop analysis benefit from several valuable features, including:

• user-selectable PV cycles for loop analysis
• correction for parallel conductance (saline bolus studies)
• simultaneous display of loops from single or multiple subjects
• ability to review and export results to Excel
• beat-by-beat calculations
• one file per experiment
• no need for data conversion and transfer
• ability to define protocols for automation of tasks
• 21 CFR Part 11 & full glp compliance

Calculated parameters include End-Systolic Pressure-Volume Relationship (ESPVR), End-Diastolic Pressure-Volume Relationship (EDPVR), preload recruitable stroke work relationship (PRSW), arterial elastance (Ea) and stroke work.

Real-time volume signals may also be obtained using sonomicrometry.

For more information about P-V loop analysis solutions, visit http://www.emka.fr//index.php?page=30&hardware=17 or send us your request here.

studyDESIGNER® is  a complete solution for planning and organizing ecg toxicology studies and for managing data acquisition and analysis in safety pharmacology or toxicology studies.

studyDESIGNER® has been developed to make your studies easier and safer:

• daily users are guided through their choices and
• cannot change key settings
• data and file handling are performed through
• dedicated functions with full traceability
• direct and secure link from studyDESIGNER®
• database to your specific database

studyDESIGNER® runs with emka TECHNOLOGIES' field-proven software suite, including:

• iox for data acquisition and real-time processing
• ecgAUTO for in-depth analysis of ecg and cardiovascular signals

Learn more about studyDESIGNER®

Ask for a quote now! or schedule a demo !

The increase of serious adverse events, the withdrawal of drugs from the market due to cardiac safety and strict regulations, have made cardiac safety a top priority for pharmaceutical companies.  In January 2007, the Center for Business Intelligence brought together industry's leading experts in cardiac safety for a highly educational two-day summit that provided executives with practical solutions for running cardiac safety testing for pharmaceuticals and medical devices. For 2008, CBI is continuing this tradition by focusing on the timely issues that are most important to industry.

emka TECHNOLOGIES will be present at the Center for Business Intelligence's 2nd Annual Cardiac Safety Assessment meeting, at the Hilton Alexandria Mark Center, Alexandria, VA, USA, on Monday 14th and Tuesday 15th, January 2008.

Visit us in the exhibitor section. We will be happy to discuss how we can help you meet ever stricter cardiac safety requirements.

Learn more about using our products for non-invasive telemetry, ecg studies and isolated heart studies.

Our software solutions include iox2, for acquisition and cardiovascular analysis, and ecgAUTO, for advanced ecg analysis.

Further information on the conference is available here: http://www.cbinet.com/show_conference.cfm?confcode=PC08002

Did you know? emka TECHNOLOGIES has developed a double-chamber plethysmograph to investigate pulmonary function in mice, before and after exposure to a drug or other challenge. The new size was adapted from the existing double-chamber plethysmograph for rats and guinea-pigs, and offers the same possibilities.

A neck-seal divides the plethysmograph into two independent chambers, for the subject's head and the rest of its body. The direct measurement of respiration in the head chamber allows absolute values to be obtained.

The double-chamber plethysmograph for mice may also be used with the body chamber only ("head-out" configuration).

emka TECHNOLOGIES can provide you with an integrated setup, including double-chamber plethysmograph, pneumotachographs, pressure transducers, bias-flow pump, amplifier(s), interface box, iox2 data acquisition software .

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emka TECHNOLOGIES provides a range of hardware and software solutions for researchers performing pulmonary studies. Our setups can be used to study conscious unrestrained subjects (whole-body plethysmography), conscious restrained subject (double-chamber plethysmography) or anesthetized subjects, in different species (mice, rats, guinea-pigs).

We are proud to announce the launch of version 4 of our website and urge you to explore it.

We listened to our customers and, over the last few months, the site has been checked from top to bottom. Our development team has been working behind the scenes to bring you many new features:

• site search engine with advanced search capabilities
• online request form to arrange an on-site demo or receive a quote
• private access for registered visitors (registration is free and subject to approval)
• ability to maj/upload and download documents in your private area (registered visitors only),
  for support or technical help    
• meet the staff section

We remain attentive to the research community. Let us know what you think of the site (you can also now rate any page from the website). And keep telling us how we can continue to provide the products and services you need!

Apply for registration today! In addition to gaining private access, registered visitors are assigned a salesperson, who will only be too happy to answer your questions, to discuss your requirements and to tell you how emka TECHNOLOGIES can make your research smarter!

RSS stands for 'Really Simple Syndication' or 'Rich Site Summary', depending on whom you choose to believe.

It is a service that allows web sites to push content ('feed') out to users, or to other web sites. Users can thus receive content from emka TECHNOLOGIES without the need to visit the website.

RSS feeds allow you to stay up to date with the latest news and features you want from emka TECHNOLOGIES.

how can I use RSS?
To receive an RSS feed, you must 'subscribe' to it. Subscription means that you tell your computer where to automatically collect information from emka TECHNOLOGIES (there is nothing to pay!)

You need a news reader to subscribe to an RSS feed. Most news readers are free to use. News readers are provided as part of modern web browsers (Internet Explorer 7, Firefox, Opera and Safari), as stand-alone applications, or as web-based services. (A list of popular news readers is provided below.)

Depending on your choice, you can then subscribe to the content in various ways, such as dragging the URL of the RSS feed into your news reader or by cutting and pasting the URL into a new feed.

The URL of the RSS feed for emka TECHNOLOGIES to paste into your news reader is: http://www.emka.fr/rss.php

- if you are using a web-basedbrowser, you can simply click on the RSS icon  on the website to subscribe.  

what News Readers are available?
A list of some of the most popular current readers is provided below. This is divided into three categories: readers that work as stand-alone applications; readers that are part of web browsing software, and readers that are available as a service from a web site.

Web Based
Bloglines
http://bloglines.com/
Free - registration required
Very straightforward to setup; easy-to-use interface.

Browser Based
inforss
http://inforss.mozdev.org/
Requires Firefox
Free to use. This scrolls across the bottom of the browser window, or alternatively provides an option of popup when a new story arrives.

Sage
Requires Firefox
http://sage.mozdev.org/
Firefox feed reader extension. Free and easy to use, but with limited options.

PC Software
FeedDemon, by Bradbury Software
http://feeddemon.com/feeddemon/index.asp
Dedicated RSS reader with a clean, slick, user interface, similar to an email client

Newz Crawler
http://www.newzcrawler.com/
Dedicated RSS reader, again with an email-style interface

Mac OS X Software
NetNewsWire
http://ranchero.com/netnewswire/

NewFire
http://www.newsfirerss.com/
Dedicated RSS reader